Characterization of Spatial Dynamics of Fmri Data in White Matter Using Diffusion-Informed White Matter Harmonics

Citation:

Behjat H, Aganj I, Abramian D, Eklund A, Westin C-F. Characterization of Spatial Dynamics of Fmri Data in White Matter Using Diffusion-Informed White Matter Harmonics. Proc IEEE Int Symp Biomed Imaging. 2021;2021 :1586-90.

Date Published:

2021 Apr

Abstract:

In this work, we leverage the Laplacian eigenbasis of voxel-wise white matter (WM) graphs derived from diffusion-weighted MRI data, dubbed WM harmonics, to characterize the spatial structure of WM fMRI data. Our motivation for such a characterization is based on studies that show WM fMRI data exhibit a spatial correlational anisotropy that coincides with underlying fiber patterns. By quantifying the energy content of WM fMRI data associated with subsets of WM harmonics across multiple spectral bands, we show that the data exhibits notable subtle spatial modulations under functional load that are not manifested during rest. WM harmonics provide a novel means to study the spatial dynamics of WM fMRI data, in such way that the analysis is informed by the underlying anatomical structure.

Last updated on 06/10/2021