Neuroimage Analysis Center
"understanding the human brain through imaging"


Corticospinal Tract Modeling for Neurosurgical Planning by Tracking through Regions of Peritumoral Edema and Crossing Fibers using Two-Tensor Unscented Kalman Filter Tractography

Results from case 1 with left frontal metastatic sarcoma. T2-weighted images demonstrate a lesion with significant peritumoral edema and a region of interest (ROI) is placed on the boundary of the lesion (a) to specify the zoomed-in region (bottom row). Using single- tensor streamline tractography (red fibers), there is no fiber tract that runs through the edematous area (b). Two-tensor unscented Kalman filter (UKF) tractography (green) shows tracing of corticospinal tract (CST) portions that run through the edematous area (c). 3D ellipsoid glyphs show the diffusion tensor model (DTI) in the ROI (d), where isotropic diffusion is shown by red and orange glyph colors. Single- tensor streamline tractography traced fiber tracts only where the tensor ellipsoids are apparently anisotropic (e). In contrast, two-tensor UKF tractography could track in regions with isotropic diffusion (f, arrow)


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The Neuroimage Analysis Center (NAC) develops image processing and analysis techniques for basic and clinical neurosciences. The NAC research approach emphasizes both specific core technologies and collaborative application projects. The activities of the NAC are centered at the Harvard Medical School and the Surgical Planning Laboratory at the Brigham and Women's Hospital in Boston, with collaborators throughout the United States and the rest of the world.

The NAC is a Biomedical Technology Resource Center supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) (P41 EB015902). It was supported by the National Center for Research Resources (NCRR) (P41 RR13218) through December 2011.

Surgical Planning LaboratoryBrigham and Women's HospitalHarvard Medical SchoolNational Center for Research Resources (NCRR)National Institute of Biomedical Imaging and Bioengineering (NIBIB)National Institute of Health (NIH)