Moscufo N, Guttmann CRG, Meier D, Csapo I, Hildenbrand PG, Healy BC, Schmidt JA, Wolfson L. Brain regional lesion burden and impaired mobility in the elderly. Neurobiol Aging. 2011;32(4):646–54.
Abstract
This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects >=75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed (r=0.4, p
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